The feasibility of implementing text messaging system to support smoking cessation for smokers in Hanoi

ISSN: 1859-2171  
e-ISSN: 2615-9562  
TNU Journal of Science and Technology  
225(05): 69 - 76  
THE FEASIBILITY OF IMPLEMENTING TEXT MESSAGING SYSTEM  
TO SUPPORT SMOKING CESSATION FOR SMOKERS IN HANOI  
Doan Thi Hue1*, Nguyen Thi Trang2, Donna Shelley3, Kim Bao Giang4, Nguyen Truong Nam4  
1TNU - University of Medicine and Pharmacy, 2Institute of Social & Medical Studies,  
3NYU Langone Hospitals, 4Hanoi Medical University  
ABSTRACT  
The study was carried out to assess the feasibility of implementing text messaging system to  
support smoking cessation smokers in Hanoi. This was a pilot study done on 40 smokers in Hanoi.  
The participants received short message service texting within 6 weeks to get smoking cessation  
support. The study was an intervention one which compared the participants’ smoking before and  
after the intervention done. The participants were interviewed directly with a questionnaire that  
includes the following contents: suitability of number/ content of messages, frequency/ time of  
sending messages, use of received messages, interaction with the program, satisfaction with the  
messaging system, and change in smoking behavior. The results showed that there were 82.5%  
reading/using text messages daily, 82.5% interacted with program – by 2-way text messaging;  
90% of the participants found the messages useful; 97.7% were satisfied with the program. The  
researched subjects commented that the program was easy to use. 20% of the participants quit  
smoking/ waterpipe tobacco completely; 15% quit smoking but still smoke waterpipe tobacco.  
Smoking behavior changed positively compared to the initial survey; the statistical significance  
included the number of cigarettes/waterpipe tobaccos smoked a day, the status of smoking  
cigarettes/waterpipe tobacco (p <0.001). The rate of research subjects who tried to stop smoking  
cigarettes/pipe tobacco in 4 weeks was quite high (52.5% before the intervention and 25% after the  
intervention). This study provided evidence of the feasibility of the use of a text messaging  
program to provide intervention supports in smoking cessation for Vietnamese people.  
Key words: smoking cessation; Interventions, adults; SMS texting, mhealth  
Received: 25/3/2020; Revised: 29/4/2020; Published: 29/4/2020  
TÍNH KHẢ THI CỦA VIỆC TRIỂN KHAI HỆ THỐNG TIN NHẮN  
HỖ TRỢ CAI THUỐC LÁ CHO NGƯỜI HÚT THUỐC TẠI HÀ NỘI  
Đoàn Thị Huệ1*, Nguyễn Thị Trang2, Donna Shelley3, Kim Bảo Giang4, Nguyễn Trương Nam4  
1Trường Đại học Y Dược – ĐH Thái Nguyên, 2Viện Nghiên cứu Y - Xã hội học,  
3Bệnh viện NYU Langone, 4Trường Đại học Y Hà Nội  
TOM TẮT  
Nghiên cứu này được thực hiện nhằm đánh giá tính khả thi của việc triển khai hệ thống tin nhắn (SMS)  
hỗ trợ cai thuốc lá. Nghiên cứu thử nghiệm trên 40 người hút thuốc lá tại Hà Nội. Đối tượng nghiên cứu  
nhận tin nhắn điện thoại hỗ trợ cai thuốc lá trong 6 tuần. Thiết kế nghiên cứu can thiệp, so sánh trước và  
sau can thiệp. Đối tượng nghiên cứu được phỏng vấn trực tiếp bằng bộ câu hỏi gồm: sự phù hợp số  
lượng/nội dung SMS, tần suất/thời gian gửi tin, sử dụng tin nhắn nhận được, tương tác với chương  
trình, hài lòng với chương trình tin nhắn; thay đổi hành vi hút thuốc. Kết quả nghiên cứu cho thấy: có  
82,5% đối tượng nghiên cứu đọc/ sử dụng tin nhắn hàng ngày, 82,5% người tương tác với chương trình  
- SMS hai chiều, 90% người thấy tin nhắn hữu ích, 97,7% hài hòng. Đối tượng nghiên cứu nhận xét  
chương trình dễ sử dụng và 92,5% bạn bè người thân đều khuyến khích đối tượng tham gia sử dụng  
chương trình. Có 20% đối tượng nghiên cứu bỏ thuốc lá/thuốc lào hoàn toàn, 15% đối tượng nghiên  
cứu bỏ thuốc lá nhưng vẫn hút thuốc lào. Hành vi hút thuốc lá thay đổi tích cực so với khảo sát ban đầu.  
Có ý nghĩa thống kê bao gồm số lượng điếu thuốc lá/thuốc lào hút/ngày, tình trạng hút thuốc lá/thuốc  
lào (p<0,001). Tỷ lệ đối tượng nghiên cứu từng cố gắng cai thuốc lá/thuốc lào trong 4 tuần khá cao  
(trước can thiệp: 52,5%, sau can thiệp: 25%). Như vậy, việc áp dụng một chương trình SMS hỗ trợ can  
thiệp cai nghiện thuốc lá cho người Việt Nam là có tính khả thi.  
Từ khóa: cai thuốc lá; can thiệp; người trưởng thành; tin nhắn SMS; ứng dụng y tế điện thoại.  
Ngày nhận bài: 25/3/2020; Ngày hoàn thiện: 29/4/2020; Ngày đăng: 29/4/2020  
* Corresponding author. Email: [email protected]  
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Some authors have studied the feasibility and  
acceptability of text messaging intervention  
programs on elderly people living in rural  
areas in the US; the results showed that 81% of  
the participants could read all the information  
and found that text messages very useful as a  
measure to support smoking cessation; the rate  
of smoking cessation in the intervention group  
decreased significantly [5], [10], [11], [12]. In  
Vietnam up to now, there have not been any  
research projects on the implementation of  
mobile phone-based messaging system to  
support smoking cessation.  
1. Introduction  
According to estimates from the 2015  
smoking survey on adults (aged 15 and over),  
Vietnam is a country with the high rate of  
smoking in Asia [1]. The smoking rate in  
adults in Vietnam was 22.5%, of which,  
45.3% was males, and 1.1% was females; in  
total there were 15 million adults smoking  
cigarettes and water-pipe tobacco [2].  
Tobacco use is the leading, but interventional  
and preventable, common cause of many fatal  
diseases in the world. Tobacco use increases  
the risk of myocardial ischemia more than 2.5  
times, lung cancer more than about 20 times,  
etc [3], [4]. The total cost of treatment and  
loss of ability to work due to illnesses and  
premature deaths in 5 common tobacco-  
related diseases including lung cancer, upper  
digestive-respiratory tract cancers, myocardial  
infarction, stroke, and COPDs is more than  
VND 23,000 billion per year [5].  
Institute of Medical Research - Sociology  
(ISMS), New York University of Medicine  
(NYUSOM), and Hanoi Medical University  
have cooperated to implement the project of  
developing and testing the mobile phone-  
based message system to support smoking  
cessation in Nam Tu Liem District, Hanoi  
city. The study was carried out to assess the  
feasibility of implementing text messaging  
system to support smoking cessation smokers  
in Hanoi.  
In recent years, in Vietnam, the activities of  
preventing tobacco-related harms have made  
significant progress and achievements  
including communication activities on health  
education, building smoke-free environments,  
controlling sources of supplying tobacco  
products, setting up a fund to prevent tobacco  
harms from tobacco enterprises’ revenues.  
However, activities to support smoking  
cessation have just been implemented in some  
Central and provincial hospitals [6], [7].  
2. Research subjects and methods  
2.1. Research subjects  
Criteria for selecting participants: Participants  
are smokers (including cigarette/ware pipe  
dua users) who are 21 - 55 years old, smoke  
cigarettes (including water-pipe tobacco)  
daily and use 5 or more cigarettes per day;  
they are now living in Nam Tu Liem district;  
they wish to quit smoking/water-pipe  
tobacco; they consider or intend to quit in the  
next month; they own at least one mobile  
phone; they desire to receive mobile phone  
messages of support for quitting; they are not  
taking any quit smoking counseling or using  
nicotine patches or other smoking cessation  
medications.  
The rapid development of mobile medical  
technology has offered unprecedented  
opportunities to improve health services and  
bring them to more people. Mobile text-based  
short messaging (SMS) can provide smoking  
cessation assistance to people in the  
community, and the effectiveness of SMS  
programs has been reported in other countries  
in the world with different population groups  
[8]-[10]. There have been more and more  
studies proving the effectiveness of text-based  
smoking cessation interventions, but these  
have largely been done in western countries.  
Selection method: Medical collaborators  
(MCs) introduced the study through  
community meetings and offered invitations  
to participate in the study. Smokers were  
invited to come for the baseline survey, were  
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explained about the research carefully, agreed  
to participate in the study and met the criteria  
for selecting study subjects.  
Data collection methodology:  
- Baseline assessment: direct interviews using  
the questionnaires covering topics such as:  
demographics, smoking history, use of other  
addictive substances, family smoking policy,  
three top factors that make people want to  
smoke, social norms on tobacco use, level of  
confidence in quitting smoking, social  
behavior of smoking, and getting social  
support to quit and use mobile phones and  
text messaging features on mobile phones  
2.2. Research location  
Ha Noi is a densely populated city with 29  
districts. The research got support from the  
Nam Tu Liem District Health Center during  
the recruitment of participants. Nam Tu Liem  
District has an area of 32.27 km2 and a  
population of 236,700 people (12/2017).  
Thus, the study was conducted in 2 wards of  
Nam Tu Liem District in Hanoi City [8].  
- Assessment after 4 weeks of intervention:  
direct interview using the pre-designed  
questionnaires covering the following  
contents: Feasibility: 1) rate of the smokers  
with eligibility, 2) recruitment rate; 3)  
retention rate; Suitability: quantity / content  
of appropriate messages, frequency/time of  
delivering messages, use of received  
messages, interaction with the program  
(frequency of 2-way messaging feedbacks,  
responses to daily surveys, responses to  
weekend surveys), satisfaction with the text  
messaging system; Changes in smoking  
behaviors: Smoking cessation is measured by  
not smoking even once in the past 4 weeks  
and confirmed by measuring carbon  
monoxide level (CO <10 ppm), attempts to  
quit, attempts to cut down on smoking  
tobacco, water-pipe tobacco.  
2.3. Research design  
The pilot study started from April to  
September 2018, delivering SMSs to 40  
subjects to assess the feasibility of the text  
messaging system. The study included a  
baseline survey and a survey after 6 weeks of  
intervention.  
Intervention description: The messaging  
system was designed based on two messaging  
systems: smokefree.gov/txt and Text2Quit  
with the technical support from Voxiva nc,  
tested in western countries and completely  
free. These two message libraries have been  
translated from English into Vietnamese in  
the right process. The total number of  
messages in the entire process was 188,  
divided into the following stages: The  
messages before the day of smoking was 34  
messages; The day of quitting smoking: 4  
messages; After the day of quitting smoking:  
83 messages; Messages of tips: 22 messages;  
Daily survey messages: 1 message / day  
(Fig.1) [8].  
2.4. Data analysis  
Stata 12.0 software was used to analyze data  
2.5. Ethical issues in research  
Subjects invited to participate in the study  
were fully explained about the content,  
purpose and rights of participants, and signed  
agreements to participate in the research. The  
study was approved by the ethics council of  
New York Medical University (NYUSOM),  
the Institute of Medical Research - Sociology  
(ISMS) and Hanoi Medical University.  
3. Research results  
Figure 1. The process of sending messages and  
the number of messages delivered in 6 weeks  
3.1. Characteristics of participants  
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Table 1. Characteristics of participants  
Features (N = 40)  
n
%, mean (SD)  
Gender  
Male  
Female  
40  
0
100  
0
Age (mean)  
38.8 (+ 10.7)  
Marital status  
Married  
Single/Never married  
Education  
33  
7
82.5  
17.5  
Junior Secondary School  
Secondary School  
Vocational education /College  
University/Post-graduate  
Occupation  
11  
15  
6
27.5  
40.0  
15.0  
17.5  
7
Civil servants  
Working for foreign agencies  
Business/freelance  
10  
9
14  
7
25.0  
22.5  
35.0  
17.5  
Househusband wife)/  
unemployed/students/retirement  
Total household income / last 12 months (n=39)  
< VND 50 million  
VND 50 million - < VND100 million  
VND100 million - < VND 300 million  
> VND 300 million  
The first smoking time of the day after getting up  
< less than 5 minutes  
5 - 30 minutes  
6
29  
2
15.0  
72.5  
5.0  
2
5.0  
6
14  
4
15.0  
35.0  
10.0  
40.0  
31 – 60 minutes  
> 60 minutes  
16  
Smoking status  
Smoking only cigarettes  
Smoking both cigarettes and water-pipe  
tobacco  
17  
23  
42.5  
57.5  
Mobile phone usage  
Using smartphones  
Using ordinary mobile phones  
Numbers of delivered/received messages/week  
1 - 10  
34  
6
85.0  
15.0  
7
24  
9
22.5  
60.0  
17.5  
11 - 50  
> 50  
Table 1 reveals that 100% of the participants were male; the average age was 38.8 years old, 82.5%  
married; most of them had the education level from high school up to university (40%, 15% and  
17.5 %); 25% of the participants were civil servants and 35% of people were freelance traders. The  
family income from 50 million to <100 million accounted for the highest rate of 72.5%. 57.5% of  
smokers/pipe tobacco smokers; 85% of participants use smartphones; 60% send/receive 11- 50  
messages /week.  
3.2. The feasibility  
The results in table 2 reveal that most research participants commented that the number of messages  
of the program was moderate (80%); the frequency of reading messages was 82.5%. They rated the  
overall experience of the text messaging program very positively; 90% rated the messages quite  
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useful/very useful; 82.5% interacted with the program; only 78.8% responded to the message in the  
correct syntax; the program satisfaction rate was very high with 97.5%.  
Table 2. Assessing the participants’ overall experience with the program after 6 weeks  
Features  
n
%
Number of messages received from the program  
Too small  
Moderate  
Too big  
1
32  
7
2.5  
80.0  
17.5  
Frequency of reading messages  
Sometimes  
7
33  
17.5  
82.5  
Usually/Always  
Frequency of applying the information from the program  
Sometimes  
24  
16  
60.0  
40.0  
Usually/Always  
The level of concern if others see the messages you receive from the program  
Worry-free  
39  
1
97.5  
2.5  
Worry a little / worry a lot  
Overall overview of the usefulness of the messages  
A little useful  
4
36  
10.0  
90.0  
Quite useful/very useful  
The level of your satisfaction with the program  
Unsatisfied  
1
2.5  
Satisfied/Very satisfied  
Interaction with the program (2-way messages)  
Feedback messages in the correct syntax (n = 33)  
39  
33  
26  
97.5  
82.5  
78.8  
Table 3. Assessment of participants’ general experience of the program after 6 weeks of intervention  
Features  
Agree/Strongly  
agree (%)  
Mean Scores  
(Mean)  
25.8  
Expect efficiency from the program (score range from 8 to 32)a  
Messages to help with smoking cessation  
Learn a lot via using the program  
95.0  
95.5  
97.5  
3.15  
3.27  
3.10  
Text messaging program helps me gain  
confidence to quit smoking  
The messages motivated me to quit smoking  
The messages helped me deal with cravings for smoking  
Get motivated to try to quit smoking  
97.5  
92.5  
92.5  
97.5  
92.5  
3.27  
3.22  
3.20  
3.42  
3.12  
6.4  
3.17  
3.2  
6.2  
Trust the information in the messages  
Feel the messages were designed suitably  
Expectattempts to quit smoking (score range2-8)b  
Use the text messaging program easily  
95.0  
97.5  
The text messaging program was easy to use  
Social influences (score range 2-8)c  
People who are important to me think that I should use the  
text messaging program  
92.5  
90.0  
3.15  
People who influence me think I should use the text  
messaging program  
3.07  
Good conditions (score range 3-12)d  
9.4  
Have necessary knowledge necessary to use the program  
The messages are easy to understand  
Text messaging program suitable for my mobile phones  
Motivation for enjoyment (score range 5-20)e  
The use of text messaging program was funny  
Desire to use the text messaging program  
92.5  
92.5  
95.0  
3.07  
3.17  
3.17  
14.9  
3.02  
3.17  
87.5  
87.5  
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Mean Scores  
(Mean)  
2.00  
agree (%)  
12.5  
The use of text messaging program was boring  
The messages bothered me  
7.5  
2.02  
Using the text messaging program helped me entertain  
62.5  
2.67  
6.1  
Values/price (score range 2-8)f  
Worthy of the time I spent  
92.5  
85.0  
3.07  
3.05  
The free messaging program has increased my possibility to  
use the program  
Habits (score range 2-8)g  
5.8  
2.82  
2.95  
6.0  
3.02  
2.95  
Want to use the messaging program every day  
The use of the messaging program has become natural  
Intended behaviors (score range 2-8)h  
Want to continue to use the program if available  
Will use themessaging program every day if theprogram isavailable  
85.0  
87.5  
85.0  
82.5  
Table 3 reveals that most of research participants highly appreciate and have a positive view on  
the text messaging program for interventions in smoking cigarettes/water-pipe tobacco cessation.  
More than 95% of subjects expected to quit smoking after joining the program. More than 95% of  
smoking cessation made attempts; more than 90% rated the program facilitated smoking cessation.  
More than 85% of the participants found the program worthy of the time they spent, and wanted to  
continue using the program if available (85%). However, 7.5% thought the message bothered them.  
3.3. Change in smoking behaviors after intervention  
Table 4. The rate of total abstinence within 6 weeks (having not smoked in the past 7 days and CO  
breathing <10 ppm)  
Features  
Quit smoking cigarettes/water-pipe tobacco completely  
Quit smoking cigarettes, but still smoke water-pipe tobacco  
Still smoke both cigarettes and water-pipe tobacco  
n
8
6
%
20.0  
15.0  
65.0  
26  
Table 4 shows that 20% of the participants quit smoking cigarettes/water-pipe tobacco completely;  
15% stopped smoking cigarettes, but still continued smoking water-pipe tobacco. The percentage of  
participants still smoked cigarettes/water-pipe tobacco was 65 %.  
Table 5. Change in smoking behaviors after 6 weeks of interventions  
Features  
Baseline survey  
(n, %, Mean  
+ SD)  
After 6 weeks  
(n, %, Mean  
+ SD)  
p
Number of cigarettes smoked/day, average  
Number of water-pipe tobacco smoked/day, average  
Frequency of smoking cigarettes now  
Sometimes  
18.0  
11.8  
3.0  
2.0  
<0.001  
<0.005  
2.5  
97.5  
53.8  
46.2  
<0.001  
Every day  
Frequency of smoking water-pipe tobacco now  
Sometimes  
34.8  
65.2  
56.3  
4.4  
Every day  
< 0.1  
No cigarette use/quit attempts made over 4 weeks after  
the program started  
21 (52.5%)  
No water-pipe tobacco use/quit attempts made over 4  
weeks after the program started  
10 (25%)  
Table 5 reveals that the changes were statistically significant in the number of cigarettes  
smoked/day, smoking status (p <0.001); the number of cigarettes smoked per day (p <0.005),  
current status of water-pipe tobacco smoking (p <0.1). There were 52.5% of participants who  
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tried to quit smoking cigarettes and 25% who tried to stop smoking water-pipe tobacco within 6  
weeks participating in the program.  
4. Discussion  
smoking status (p <0.001), number of  
cigarettes smoked per day (p <0.005),  
waterpipe tobacco smoking (p <0.1). The rate  
of research participants who tried to quit  
smoking cigarettes/ water-pipe tobacco within  
6 weeks was quite high.  
4.1. Feasibility  
Most subjects participated in the reading and  
using messages programs every day (82.5%).  
The level of interaction of research  
participants with the program was very high,  
which is similar to the results found in other  
studies [12], [13]. Our results once again  
show that text messaging-based smoking  
cessation intervention programs are highly  
feasible, because the messages in the program  
are directly delivered to the smokers for the  
sake of smoking cessation [11], [12]. The  
relatively high interaction between research  
participants and the intervention program  
could be due to the average age group in the  
study was only 38.8 (+ 10.7), and most  
research participants have smartphones  
(85%); 90% of them found the messages  
useful / very useful; 82.5% interacted with the  
program via 2-way messages, but only 78.8%  
responded to the messages with the correct  
syntax; 97.6% were satisfied with the program.  
The participants found the program easy to use.  
Overall, the study proves that a text messaging-  
based support program for smoking cessation is  
likely to be accepted in Vietnam.  
5. Conclusion  
This study demonstrated the advantages of  
applying a supportive messaging program to  
help a group of smokers in Hanoi to quit  
smoking, and showed that a program can be  
designed to meet all the needs of  
interventions for all groups of smokers in  
other areas. It might suggest that there should  
be a need to expand this smoking cessation  
intervention program: They rated the overall  
experience of the text messaging program  
very positively; 90% rated the messages quite  
useful/very useful; 82.5% interacted with the  
program; only 78.8% responded to the  
message in the correct syntax; the program  
satisfaction rate was very high with 97.5%.  
Most research participants commented that  
the number of messages of the program was  
moderate (80%); the frequency of reading  
messages was 82.5%. Most of research  
participants highly appreciate and have a  
positive view on the text messaging program  
for interventions in smoking cigarettes/water-  
pipe tobacco cessation. More than 95% of  
subjects expected to quit smoking after  
joining the program.  
4.2. Change in smoking behaviors  
Although the result of quitting is not the main  
objective in this study, there are still 8  
participants who completely quit smoking  
cigarettes/water-pipe tobacco (20%),  
6
The text messaging-based support program  
for smoking cessation can be used as an  
independent intervention supporting method  
or used to supplement or combine with other  
services, such as group counseling and  
telephone counseling. More than 95% of  
smoking cessation made attempts; more than  
90% rated the program facilitated smoking  
cessation. More than 85% of the participants  
found the program worthy of the time they  
participants who quit smoking cigargettes,but  
still smoked water-pipe tobacco (15%). Our  
results are similar to those carried out in some  
other countries in the world [12] and [14].  
After 6 weeks of intervention, 65% still  
smoked. However, smoking cigarettes/  
smoking waterpipe tobacco behaviors have  
changed positively compared to the baseline  
survey; statistical analyses  
include the  
number of cigarettes smoked/day (p <0.001),  
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225(05): 69 - 76  
[5]. World Health Organization, "WHO report on  
the global tobacco epidemic 2019", 2019.  
cco/global_report/en/. [Accessed July 29, 2019].  
[6]. Bach Mai Hospital, "An Evaluative Study of  
the Smoking Cessation Quitlines at Bach Mai  
Hospital," Report from VINACOSH, 2016.  
[7]. V. P. Dang and N. K. Luong, Ministry of  
Health of Viet Nam Smoking Cessation  
Guidelines, 2018.  
[8]. R. S. Donna, and N. T. Nguyen, "Feasibility  
and Acceptability of a Text Messaging  
Intervention to Increase Smoking Cessation in  
Vietnam", 2017. [Online]. Available:  
mhealth-R21CA225852.aspx. [Accessed Aug.  
28, 2019].  
spent, and wanted to continue using the  
program if available (85%). However, 7.5%  
thought the message bothered them. 20% of  
the participants quit smoking cigarettes/water-  
pipe tobacco completely; 15% stopped  
smoking cigarettes, but still continued  
smoking water-pipe tobacco. The percentage  
of participants still smoked cigarettes/water-  
pipe tobacco was 65 %. There were 52.5% of  
participants who tried to quit smoking  
cigarettes and 25% who tried to stop smoking  
water-pipe tobacco within  
6
weeks  
participating in the program (p <0.001).  
Although this study provides evidence of  
feasibility, future large-scale studies will be  
needed to evaluate the effectiveness of the  
program in other areas and across the country.  
[9]. X. B. Tran et al., "Feasibility of e-Health  
Interventions on Smoking Cessation among  
Vietnamese Active Internet Users," Int. J.  
Environ. Res. Public Health, 15(165), pp. 2-8,  
2018.  
REFERENCES  
[10]. S. Spohr et al., "Efficacy of SMS Text  
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vietnam-global-adult-tobacco-survey-2015.  
[Accessed June 18, 2019].  
[3]. S. David, "How Tobacco Smoke Causes  
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[4]. National Center for Chronic Disease  
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(US), Atlanta (GA), 2014.  
Message  
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for  
Smoking  
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[11]. D. Noonan et al., "Feasibility of a text-based  
smoking cessation intervention in rural older  
adults," Health Educ. Res., 33(1), pp. 81-88,  
2018.  
[12]. G. Kruse et al., "Feasibility of a Proactive  
Text Messaging Intervention for Smokers in  
Community Health Centers: Pilot Study,"  
JMIR Form Res., 2(1), p. e11, 2018.  
[13]. C. A. Spears et al., "Text Messaging to  
Enhance  
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MHealth UHealth, 7(1), p. e11246, 2019.  
[14]. D. Blitchtein-Winicki et al., "Feasibility and  
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76  
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